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Soloway MS, Schellhammer PF, Smith JA, Chodak GW, Vogelzang NJ, Kennealey GT "Bicalutamide in the treatment of advanced prostatic carcinoma: a phase II noncomparative multicenter trial evaluating safety, efficacy and long-term endocrine effects of monotherapy.

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First, the Panel began a literature search and data extraction to capture clinical treatment outcomes for patients with clinical stage T1 to T2N0M0 prostate cancer.

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Prostate specific antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma.

In certain situations, AR mutations cause antagonists to induce an agonist conformation, resulting in AR activation rather than inhibition.

Investigating BRCA Mutations: A Breakthrough in Precision Medicine of Castration-Resistant Prostate Cancer.

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Background: Gonadotropin-releasing hormone (GnRH) agonist has been used for androgen-deprivation therapy (ADT) for prostate cancer (PCa).

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Among the complications associated with treatments for clinically localized prostate cancer, those reported most often and with the greatest degree of variability were: incontinence and other genitourinary toxicity (i.

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In an attempt to eliminate all androgen stimulation of cancer cells, some doctors use anti-androgens along with surgical or medical castration.

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COURSE OBJECTIVE: The purpose of this course is to enable healthcare professionals to understand the epidemiology, diagnosis, and treatment of prostate cancer; approaches to prostate cancer screening and prevention; and evaluation of nursing and medical interventions for patients with prostate cancer and their significant others.

Most often prostate cancer grows slowly and is confined initially to the prostate gland, causing no serious harm and requiring little or no treatment.

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This is unsurprising, because the analysis lacked statistical power to detect a significant difference in cause-specific mortality in light of the low number of prostate cancer-related deaths (14 patients on CAB and 22 on LHRH-A monotherapy).

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Sociologists at Rutgers University noted that middle-aged men with strongly idealized masculinity are almost 50% less likely than other men to seek preventive healthcare.

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Osteoporosis is common in prostate cancer patients receiving long-term continuous hormonal therapy, especially slender white men, men with positive family history of osteoporosis, and men taking steroids.

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Some therapists also recommend cleansing of the bowel (intestines) by putting liquid into the back passage (enemas).

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Other biological response modifier therapies attack specific cancer cells, which may help keep them from growing or kill them.

Kaiser-Permanente, the University of Pennsylvania, and the Henry Ford Health System have also developed their own disease management programmes.

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Due to their salience, the Panel devoted special attention to these complications by highlighting findings from several of the extracted case series.

Option: Active surveillance, interstitial prostate brachytherapy, external beam radiotherapy, and radical prostatectomy are appropriate monotherapy treatment options for the patient with low-risk localized prostate cancer.

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Source: Journal of the American Medical Association, July 27, 2005.

This phase II study explored bicalutamide in AR-positive, estrogen receptor (ER), and progesterone receptor (PgR)-negative metastatic breast cancer.

Often, though, the spermatic cord is still present as well as some surrounding testicular structures, thus preventing the appearance of an “empty scrotum.

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In prostate cancer, the rate of proliferation is higher than that of death, resulting in continuous net growth.

Just take the next dose at your regular time.

There is no clinical trial experience re-administering XTANDI to patients who experienced a seizure, and limited safety data are available in patients with predisposing factors for seizure.

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