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Fact Sheet N401. May 2015. World Health Organization.

1 Two azoles posaconazole, fluconazole and an echinocandin, micafungin, are the firstline agents for this purpose see Table 2 for cellular mechanisms of firstline agents.

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These investigators also evaluated the relationship of clinical response and TPMT concentration in 52 patients who had been treated with a combination of prednisolone and azathioprine for at least 1 year, and the clinical response was considered favorable if there was no recurrence of pemphigus vulgaris in the first year of treatment.

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Chapters 5-9 of the full version of the original guideline document; see the "Availability of Companion Documents" field).

There are still several medical therapy options which include azathioprine or 6-mercaptopurine, methotrexate, adalimumab (Humira), certolizumab (Cimzia), natalizumab (Tysabri).

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Treatment with azathioprine alone at a dose of 2 mg per kilogram per day reversed the cushingoid facies and weight gain that had been associated with prednisolone therapy in 44 percent of our patients (other complications were rare), and most of the patients reported that they felt better (or at least did not feel worse), despite the development of arthralgias after the prednisolone had been withdrawn.

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The available case analysis method is preferred to an intention-to-treat with imputation analysis (ITT), in order to avoid making assumptions about the participants for whom outcome data were not available, and furthermore assuming that those with missing outcome data have the same event rate as those who continue.

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Both the acute cholestasis and the chronic nodular regeneration caused by azathioprine improve upon stopping the medication, but instances of progression to hepatic failure despite discontinuation of azathioprine have been reported with both syndromes.

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