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1 Two azoles posaconazole, fluconazole and an echinocandin, micafungin, are the firstline agents for this purpose see Table 2 for cellular mechanisms of firstline agents.

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Chapters 5-9 of the full version of the original guideline document; see the "Availability of Companion Documents" field).

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The available case analysis method is preferred to an intention-to-treat with imputation analysis (ITT), in order to avoid making assumptions about the participants for whom outcome data were not available, and furthermore assuming that those with missing outcome data have the same event rate as those who continue.

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Both the acute cholestasis and the chronic nodular regeneration caused by azathioprine improve upon stopping the medication, but instances of progression to hepatic failure despite discontinuation of azathioprine have been reported with both syndromes.

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