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I've had hyperthyroidism for 3 years now. Being hyperthyroid however without clear diagnosis for quite some time was a trial for me. I had many different symptoms that used to make my life a lot more difficult but I was trying hard to be patient while my doctor was carrying out different tests to define my condition. Then when the diagnosis was settled he started testing different medications to select a better treatment for me. I tried to be patient in spite of constant panic attacks, insomnia and high heart rate. But nothing seemed to help. Due to general exhaustion I looked rather gloomy - greyish skin, dull hair, skinny and passive. I couldn't work and my health worried me greatly. Then finally my doctor suggested Carbimazole. I started on a lower dose and had regular blood tests, so after about three months we found the ideal dosage for me and half a year later I stopped taking it. I am absolutely happy with the way Carbimazole worked for me and I hope the effect stays stable for long. But anyway if my thyroid level goes high again I will start on Carbimazole as it is very effective and showed no side effects.
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Alternatively, if the drug is associated with critical toxicity, we could also be reluctant to make a recommendation except absolutely the stroke reduction is at the least 1%, or NNT=a hundred (crimson line in the figure above). Beneath these circumstances, the precision is inadequate because the CI encompasses treatment effects smaller than this threshold (i.e. as small as 0.6%). A advice in favour of the intervention would nonetheless be acceptable as the point estimate of 1.3% meets the threshold, however we might rate down the quality of evidence supporting the advice by one stage for imprecision (e.g. from excessive to average).
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