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I've been on Gleevec since Aug. 24 2001 for Chronic Myelogenous Leukemia. I've had no side effects with it. The only side effect I had is when the doctor had me on both Gleevec and interferon it caused my heart function to drop. They took me off the interferon and heart function was normal. Been in remission for 11 years.
I have been on Gleevec since March 2007 when I was dignosed with Chronic Mylogenous Leukemia. I was sick for about 4 months on this drug with Nausea, leg swelling, pain so bad that I felt crippled by the end of every day and headaches. I had these symptoms even while taking Zofran with the drug. My doctor's at MSKCC told me to hang in there saying I was going to wake up one day soon and feel better than ever. And then after 4 months, they were right. I remember that I woke up one morning, stretched my arms and legs and yawned and saw the sun shining through my bedroom window and I turned to my husband and said "I feel great"! I have pretty much felt great since then and my life has thrived. I am not just a survivor, I am a thriver!
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Severe cutaneous reactions have been reported, including cases of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), some of which were fatal.
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The term adverse effect is often used interchangeably with adverse reaction, which might be better reserved for clinical phenomena occurring during drug treatment when causality cannot be or is not ascertained.
Numerical methods are an important skill set for those who will actually need to solve differential equations and other formulations that have no easy closed form expression, which applies to a lot of real-world mathematical biology.
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In adults, treatment with Gleevec may then be continued at a reduced daily dose (i.
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If at any time, you experience a discharge from your nipples, reddened or warm areas around the breast, or other unusual symptoms, notify your health care provider as soon as possible.
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If you experience severe swelling, your healthcare provider may give you diuretics ("water pills") or temporarily stop your Gleevec treatment.
An attribute common to these disorders appears to be an acquired activating mutation in the gene coding for various tyrosine kinases.
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Though experts say few of the new "targeted" therapies come close to that ideal, they do have one thing in common with Gleevec: They're all incredibly expensive.
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Gleevec was originally granted accelerated approval for the treatment of advanced or metastatic GIST in 2002.
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Gleevec can cause fetal harm when administered to a pregnant woman.
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No bioinformatics professional dealing with high-dimensional data can afford to neglect an understanding of matrix math, with many bioinformatics methods currently making use of various matrix factorizations, transformations, decompositions, and eigenwhatevers.
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In many cases, cytogenetic studies (studies of the genetic material in cells) may be done to provide additional information about the leukemia that will help the doctors determine the best treatments.
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This reduced binding capacity can be caused by either direct or indirect mechanisms, allowing a classification of Bcr-Abl mutations into two groups ().
This has worked to address everything accept swelling and stiffness!
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They will say, hey, you didn't use maximally tolerated enalapril; although, nobody does.
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CML is a slowly progressing disease in which too many of certain white blood cells are made in the bone marrow.
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While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue.
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Treatment options for chronic myeloid leukemia: imatinib versus interferon versus allogeneic transplant.
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If a remission is achieved, post-remission therapy will be done often followed by maintenance therapy.
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That is still six or seven times better than they ever could have hoped for with the previous standard therapy.
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Severe liver toxicity was observed in dogs treated for 2 weeks, with elevated liver enzymes, hepatocellular necrosis, bile duct necrosis, and bile duct hyperplasia.
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John's wort might cause there to be too much serotonin.
More than 90% of cases result from a cytogenetic aberration known as the Philadelphia chromosome (see Pathophysiology).
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The mechanism of resistance to STI571 or relapse during treatment with the drug is a subject of intense interest.
However, patients included in historical analyses on which these scores are based were treated over a decade ago.
The most frequently reported drug-related adverse reactions were edema, nausea and vomiting, muscle cramps, musculoskeletal pain, diarrhea and rash (Table 2 and Table 3 for newly diagnosed CML, Table 4 for other CML patients).
OUTLINE: This is a phase I, dose-escalation study followed by a phase II and a pilot study.